Peer-reviewed veterinary case report
Ursodeoxycholic acid protects neonatal rats from necrotizing enterocolitis: a biochemical, histopathological, and immunohistochemical study.
- Journal:
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
- Year:
- 2021
- Authors:
- Sönmezgöz, Ergün et al.
- Affiliation:
- Department of Pediatrics
- Species:
- rodent
Abstract
BACKGROUND: The pathophysiology of necrotizing enterocolitis (NEC) includes the massive production of endogenous cytokines with exaggerated activation of inflammatory pathways. Ursodeoxycholic acid (UDCA) has been used as an anti-inflammatory, antioxidant, and anti-apoptotic agent. We investigated the possible protective effects of UDCA in a neonatal rat pup model of NEC. METHODS: We randomly divided rat pups into three groups: a control group, a non-treated NEC group, and a UDCA-treated NEC group. We induced NEC by feeding formula enterally andhypoxia/reoxygenation. Intestinal samples were collected for histopathological and immunohistochemical evaluation. Blood samples were taken for biochemical analyses. RESULTS: UDCA significantly reduced the extents of terminal ileal and jejunal injuries compared to the NEC group ( < .01), reduced Bax and caspase-3 immunoreactivities (both < .01), and lowered serum levels of platelet-activating factor and intestinal fatty acid-binding protein ( < .01, = .023, respectively). CONCLUSIONS: In a rat model of NEC, UDCA protects against adverse intestinal histological, immunohistochemical, and biochemical changes. UDCA significantly reduces the effects of NEC on the rat pup intestine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32954879/