Peer-reviewed veterinary case report
Collie with loperamide poisoning treated successfully with IV lipid
By Long, Whitney M et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2017·Angell Animal Medical Center·View original on PubMed →
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Original publication title: Use of 20% intravenous lipid emulsion for the treatment of loperamide toxicosis in a Collie homozygous for the ABCB1-1∆ mutation.
- Species:
- dog
Plain-English summary
An 8-month-old male neutered Rough Collie was brought in after showing signs of confusion, anxiety, drooling, and unsteady movements, which were suspected to be due to loperamide poisoning. The dog had been given loperamide for diarrhea but developed these concerning symptoms. The veterinarian treated him with an intravenous lipid emulsion (ILE), which quickly improved his condition, and he was back to normal just three hours later. This case highlights how ILE can be effective for treating certain types of poisoning in dogs, especially those with specific genetic mutations.
People also search for: dog loperamide poisoning treatment · Rough Collie loperamide side effects · intravenous lipid emulsion for dog toxicity
Abstract
OBJECTIVE: To describe the successful treatment of loperamide toxicosis in a dog using intravenous lipid emulsion (ILE). CASE SUMMARY: An 8-month-old male neutered Rough Collie weighing 20.0 kg was given a total dose of 0.75 mg/kg loperamide over 3 days as treatment for diarrhea. The dog was subsequently evaluated for signs of dull mentation, anxiety, ptyalism and ataxia, thought to be a result of loperamide intoxication. The dog was treated with a 1.5 mL/kg IV bolus of 20% ILE solution followed by 0.25 mL/kg/min of the same solution for 2 hours. The dog's mentation improved rapidly following ILE infusion, and he was neurologically normal 3 hours after initiation of ILE treatment. The dog was subsequently found to be homozygous for the ATP-binding cassette (ABC) transporter gene (ABCB1-1∆) mutation. There were no adverse effects noted during or following ILE infusion. NEW OR UNIQUE INFORMATION PROVIDED: ILE was successful in the treatment of loperamide toxicosis in a Collie with the ABCB1-1∆ mutation. ILE may be of benefit for treatment of other intoxications in dogs with ABCB1-1Δ mutations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27992655/