Peer-reviewed veterinary case report
Use of a Fluorescent Substrate to Measure ACE2 Activity in the Mouse Abdominal Aorta.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2017
- Authors:
- Wang, Yu et al.
- Affiliation:
- Department of Pharmacology and Nutritional Sciences · United States
- Species:
- rodent
Abstract
The use of fluorogenic substrates to measure enzymatic activity is widely used to understand function within different experimental models. ACE2 is important in understanding the balance between AngII and Ang-(1-7) and how this balance could then in turn influence hypertension or other disease outcomes. Here, we describe a method to measure ACE2 activity in abdominal aorta of hyperlipidemic mice under both saline and AngII infusion.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28500595/