Peer-reviewed veterinary case report
Modified Burow's solution for treating dog ear infections compared
By Sadeghi, Sam et al.·Published in The Veterinary record·2022·Vellore Village Pet Hospital, Canada·View original on PubMed →
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Original publication title: Use of a modified Burow's solution to treat canine otitis externa: A randomised comparative clinical study.
- Species:
- dog
Plain-English summary
A group of 142 dogs with ear infections (otitis externa) were treated with either a modified Burow's solution or a standard ear medication called Surolan for 10 days. The modified Burow's solution, which contains aluminum acetate and betamethasone, cured 65% of the dogs, while Surolan cured 59%. The modified solution was found to be just as effective as Surolan and worked better for infections caused by yeast or bacteria. This suggests that modified Burow's solution is a good alternative treatment for ear infections in dogs.
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Abstract
BACKGROUND: Given the increase in antimicrobial drug resistance of several pathogens that affect the ear, there is a need for alternative therapy for canine otitis externa (OE). We hypothesised that the efficacy of modified Burow's solution would be non-inferior to that of standard treatment with Surolan. METHODS: The treatment success rate of a topical aluminum acetate 2% and betamethasone 0.1% (modified Burow's) otic solution was compared with that of a standard topical otic treatment of polymyxin B sulfate, prednisolone acetate and miconazole (Surolan) suspension in a prospective, open-label clinical trial. For 10 days, 142 dogs (232 ears) with OE were treated with modified Burow's solution or Surolan. The primary study endpoint was the cure rate at 10 days. Clinical efficacy was analysed as a secondary endpoint but without assessment for non-inferiority. RESULTS: The 10-day OE cure rate was 65% and 59% in the Burow's and Surolan groups, respectively. The modified Burow's solution was non-inferior to Surolan at a non-inferiority margin of -11.5% and was more clinically effective than Surolan in dogs with OE caused by yeast or bacteria. CONCLUSION: The results of this study demonstrate that modified Burow's solution is an effective treatment for OE in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34091924/