Peer-reviewed veterinary case report
Use of a parathyroid hormone peptide (PTH(1-34))-enriched fibrin hydrogel for the treatment of a subchondral cystic lesion in the proximal interphalangeal joint of a warmblood filly.
- Journal:
- Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
- Year:
- 2007
- Authors:
- Fuerst, A et al.
- Affiliation:
- Equine Clinic
- Species:
- horse
Plain-English summary
In this case, a warmblood filly had a bone cyst in her leg that needed treatment. The veterinarians used a special technique to clean out the cyst and then filled it with a substance made from a hormone that helps bone healing, mixed with a gel. The filly healed quickly and without any problems after the procedure. This approach shows promise for improving recovery from similar issues in horses, especially since bone cysts can be tough to treat. Overall, the treatment worked well for this filly.
Abstract
To describe the treatment of a subchondral bone cyst in the proximal phalanx with parathyroid hormone peptide-enriched fibrin hydrogel in a warmblood filly. The cyst was localized with computer-assisted orthopaedic surgery, then curetted and finally filled with parathyroid hormone fragment peptide 1-34 (PTH(1-34)) covalently attached to a fibrin hydrogel. The cyst healed quickly without any complications. This result supports the hypothesis that PTH(1-34) delivered locally in a fibrin hydrogel may improve the postoperative prognosis of surgical management of subchondral bone cysts in horses. Subchondral bone cysts are fairly common in horses. Especially in older horses, the prognosis is poor, even after surgical curettage. Therefore, different management protocols have been investigated in conjunction with surgical curettage to improve prognosis. Locally delivered PTH(1-34) seems to be a new method in the treatment of subchondral bone cysts.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17305975/