Peer-reviewed veterinary case report
Treatment of urinary incontinence in female dogs using pig bladder
By Wood, Jeffrey D et al.·Published in Journal of the American Veterinary Medical Association·2005·Northside Veterinary Hospital, United States·View original on PubMed →
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Original publication title: Use of a particulate extracellular matrix bioscaffold for treatment of acquired urinary incontinence in dogs.
- Species:
- dog
Plain-English summary
Nine female dogs with urinary incontinence that didn't respond to medication were treated with a special injection made from pig bladder tissue. Six of the dogs received this treatment, while three were given a placebo. The dogs that got the bladder tissue injection remained continent for an average of 168 days, compared to just 14 days for those who received the placebo. Two of the control dogs later received the treatment and also experienced improved continence for several months. No side effects were reported, suggesting this method could be a helpful option for managing urinary incontinence in female dogs.
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Abstract
OBJECTIVE: To evaluate use of a particulate bioscaffold consisting of the extracellular matrix (ECM) of the urinary bladder from pigs for treatment of acquired urinary incontinence in dogs resistant to medical treatment. DESIGN: Case series. ANIMALS: 9 female dogs with acquired urinary incontinence. PROCEDURE: In 6 dogs, 30 mg of particulate ECM in 1.0 mL of a carrier consisting of glycerin and saline 10.9% NaCI) solution was injected into each of 3 equally spaced sites around the circumference of the internal urethral sphincter via an endoscopic technique. In the remaining 3 dogs (control dogs), 1.0 mL of the carrier alone was injected in 3 equally spaced sites around the circumference of the internal urethral sphincter in a similar manner. RESULTS: For dogs treated with the ECM, median duration of urinary continence following treatment was 168 days (range, 84 to 616 days), whereas for the control dogs, median duration of urinary continence following the procedure was 14 days (range, 7 to 31 days). Two of the 3 control dogs were treated with the ECM at the end of the study and were continent for 119 and 252 days. No adverse effects were observed in any dog. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that endoscopically guided injection of particulate ECM into the internal urethral sphincter may be useful for the treatment of acquired urinary incontinence in female dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15825734/