Peer-reviewed veterinary case report
Platelet-rich plasma and collagen scaffold to treat partial cruciate
By Sample, Susannah J et al.·Published in PloS one·2018·Department of Surgical Sciences, United States·View original on PubMed →
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Original publication title: Use of a platelet-rich plasma-collagen scaffold as a bioenhanced repair treatment for management of partial cruciate ligament rupture in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with partial cruciate ligament (CR) tears were treated with a combination of platelet-rich plasma (PRP) and a collagen scaffold to see if it would help prevent further damage. Despite the treatment, the study found that this method did not effectively stop the progression to complete CR tears over a year. The dogs underwent surgery for their unstable stifles and received the PRP-collagen treatment in their stable stifles, but many still showed signs of worsening conditions. The results suggest that while PRP-collagen was not beneficial in preventing complete CR, monitoring through various diagnostic tests was important for understanding the progression of the injury.
People also search for: dog cruciate ligament tear treatment · PRP therapy for dog knee injury · partial cruciate ligament rupture in dogs
Abstract
Dogs are commonly affected with cruciate ligament rupture (CR) and associated osteoarthritis (OA), and frequently develop a second contralateral CR. Platelet rich plasma (PRP) is a component of whole blood that contains numerous growth factors, which in combination with a collagen scaffold may act to promote bioenhanced primary repair of ligament. This study tested the hypothesis that treatment of partial stable CR stifles with an intra-articular collagen scaffold and PRP would decrease the disease progression, synovitis and risk of complete CR over a 12-month study period. We conducted a prospective cohort study of 29 client-owned dogs with an unstable stifle due to complete CR and stable contralateral stifle with partial CR. All dogs were treated with tibial plateau leveling osteotomy (TPLO) on the unstable stifle and a single intra-articular application of PRP-collagen in the stable partial CR stifle. Dogs were evaluated at the time of diagnosis, and at 10-weeks and 12-months after treatment. We evaluated correlation between both development of complete CR and time to complete CR with diagnostic tests including bilateral stifle radiographs, 3.0 Tesla magnetic resonance (MR) imaging, and bilateral stifle arthroscopy. Additionally, histologic evaluation of synovial biopsies, C-reactive protein (CRP) concentrations in serum and synovial fluid, and synovial total nucleated cell count, were determined. Results indicated that a single application of PRP-collagen in partial CR stifles of client owned dogs is not an effective disease-modifying therapy for the prevention of progression to complete CR. Radiographic effusion, arthroscopic evaluation of cranial cruciate ligament (CrCL) damage, and MR assessment of ligament fiber tearing in partial CR stifles correlated with progression to complete CR over the 12-month follow-up period. We determined that the best predictive model for development of complete CR in PRP-collagen treated partial CR stifles included variables from multiple diagnostic modalities.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29920524/