Peer-reviewed veterinary case report
Megestrol acetate eye drops help treat eosinophilic keratitis in cats
By Stiles, Jean & Coster, Martin·Published in Veterinary ophthalmology·2016·Purdue University College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Use of an ophthalmic formulation of megestrol acetate for the treatment of eosinophilic keratitis in cats.
- Species:
- cat
Plain-English summary
A group of 17 cats with eosinophilic keratitis, a condition that causes eye irritation and inflammation, was treated with a special eye drop formulation containing megestrol acetate. Most of the cats responded well to the treatment, with 35% showing complete improvement within just a few weeks. After the initial treatment, many cats only needed the drops once a day to once a week to keep their eyes healthy. There were no side effects noted, making this treatment a safe option for managing this eye problem in cats.
People also search for: cat eye problems treatment · eosinophilic keratitis in cats · megestrol acetate for cats · cat eye drops for inflammation
Abstract
OBJECTIVE: To evaluate a compounded ophthalmic formulation of 0.5% megestrol acetate to treat eosinophilic keratitis in cats. STUDY DESIGN: Prospective study. ANIMALS STUDIED: Seventeen client owned cats with eosinophilic keratitis in one or both eyes. METHODS: Eosinophilic keratitis was confirmed by cytology. At each visit, fluorescein staining and photography were performed. Cats were initially treated q 8-12 h with 0.5% megestrol acetate in an aqueous base. Serum glucose was measured at the first or second reexamination. RESULTS: Fifteen of 17 (88%) cats had a positive response to treatment, with 6 of 17 (35%) having complete resolution at the first reexamination (2-4 weeks). Two of 17 (12%) cats did not respond to treatment. Most cats required a treatment frequency of once daily to once weekly to maintain remission of disease. No ocular irritation or systemic side effects were noted in any cat. CONCLUSIONS AND CLINICAL RELEVANCE: The use of an ophthalmic formulation of 0.5% megestrol acetate is a viable option for treating feline eosinophilic keratitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26938779/