Peer-reviewed veterinary case report
Use of antimicrobials in veterinary medicine and mechanisms of resistance.
- Journal:
- Veterinary research
- Year:
- 2001
- Authors:
- Schwarz, S & Chaslus-Dancla, E
- Affiliation:
- Institut fü · Germany
Plain-English summary
This review looks at how antibiotics are used in veterinary medicine and farming, and the potential problems that come from using these drugs too much and for different purposes. It explains how bacteria can become resistant to common antibiotics, such as tetracyclines and fluoroquinolones, by using various methods to avoid being affected by the drugs. The review also discusses how these resistance traits can be passed between bacteria through special genetic elements. Overall, it highlights the importance of understanding antibiotic resistance to help protect both animal and human health.
Abstract
This review deals with the application of antimicrobial agents in veterinary medicine and food animal production and the possible consequences arising from the widespread and multipurpose use of antimicrobials. The various mechanisms that bacteria have developed to escape the inhibitory effects of the antimicrobials most frequently used in the veterinary field are reported in detail. Resistance of bacteria to tetracyclines, macrolide-lincosamide-streptogramin antibiotics, beta-lactam antibiotics, aminoglycosides, sulfonamides, trimethoprim, fluoroquinolones and chloramphenicol/florfenicol is described with regard to enzymatic inactivation, decreased intracellular drug accumulation and modification/protection/replacement of the target sites. In addition, basic information is given about mobile genetic elements which carry the respective resistance genes, such as plasmids, transposons, and gene cassettes/integrons, and their ways of spreading via conjugation, mobilisation, transduction, and transformation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/11432414/