Peer-reviewed veterinary case report
Using bioactive 3D matrix to treat large skin wounds in pets
By Elena Yu Zakirova et al.·Published in Frontiers in Veterinary Science·2019·Department of Exploratory Research, Scientific and Educational Center of Pharmaceutics, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia, CH·View original on DOAJ →
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Original publication title: Use of Biologically Active 3D Matrix for Extensive Skin Defect Treatment in Veterinary Practice: Case Report
- Species:
- dog
Plain-English summary
A dog with large, non-healing bite wounds was treated using a new bioactive 3D matrix made from fibrin glue and special growth factors. This innovative treatment helped the dog's body create new tissue and heal the wounds effectively. After applying the matrix, the dog's wounds showed significant improvement, leading to successful healing and a positive outcome. This approach could offer new hope for similar cases in the future.
People also search for: dog skin wound treatment · bite wound healing in dogs · bioactive matrix for dog wounds
Abstract
Objectives: Large full-thickness skin defects represent a serious veterinary problem.Methods: We have developed novel bioactive 3D-matrixes based on fibrin glue Tissucol (Baxter), containing the combination of the adenoviral constructs with genes vascular endothelial growth factor 165 (VEGF165) and fibroblast growth factor two (FGF2; construct Ad5-VEGF165 + Ad5-FGF2) or multipotent mesenchymal stem cells, genetically modified with these constructs.Results:In vitro studies confirmed the biosynthesis of VEGF165 and FGF2 mRNA in the transduced cells. Ad5-VEGF165 + Ad5-FGF2- transduced multipotent mesenchymal stem cells showed an enhanced capacity to form capillary-like tubes in vitro. Bioactive 3D-matrix application enhanced granulation tissue formation and epithelialization of non-healing, large bite wounds in a dog. Successful wound healing was observed with a positive clinical outcome for the canine patient. This research and application of regenerative gene therapy alongside a novel bioactive 3D-matrix shows promising clinical applications for the future in both dogs and other mammals including humans.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3389/fvets.2019.00076