Peer-reviewed veterinary case report
Dog with large skin wound healed using new 3D bioactive matrix
By Zakirova, Elena Yu et al.·Published in Frontiers in veterinary science·2019·Department of Exploratory Research·View original on PubMed →
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Original publication title: Use of Biologically Active 3D Matrix for Extensive Skin Defect Treatment in Veterinary Practice: Case Report.
- Species:
- dog
Plain-English summary
A dog with large, non-healing bite wounds was treated using a new bioactive 3D matrix that helps promote healing. This matrix was combined with special cells that produce growth factors to encourage tissue repair. After applying this treatment, the dog's wounds showed significant improvement, with better tissue formation and healing observed. The dog had a positive recovery outcome, suggesting that this innovative approach could be beneficial for similar cases in the future.
People also search for: dog bite wound treatment · skin healing in dogs · regenerative therapy for dog wounds
Abstract
Large full-thickness skin defects represent a serious veterinary problem.We have developed novel bioactive 3D-matrixes based on fibrin glue Tissucol (Baxter), containing the combination of the adenoviral constructs with genes vascular endothelial growth factor 165 (VEGF165) and fibroblast growth factor two (FGF2; construct Ad5-VEGF165 + Ad5-FGF2) or multipotent mesenchymal stem cells, genetically modified with these constructs.studies confirmed the biosynthesis of VEGF165 and FGF2 mRNA in the transduced cells. Ad5-VEGF165 + Ad5-FGF2- transduced multipotent mesenchymal stem cells showed an enhanced capacity to form capillary-like tubes. Bioactive 3D-matrix application enhanced granulation tissue formation and epithelialization of non-healing, large bite wounds in a dog. Successful wound healing was observed with a positive clinical outcome for the canine patient. This research and application of regenerative gene therapy alongside a novel bioactive 3D-matrix shows promising clinical applications for the future in both dogs and other mammals including humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30931318/