Peer-reviewed veterinary case report
Using bioactive 3D matrix to treat large skin wounds in pets
By E. Zakirova et al.·Published in Frontiers in Veterinary Science·2019·View original on Semantic Scholar →
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Original publication title: Use of Biologically Active 3D Matrix for Extensive Skin Defect Treatment in Veterinary Practice: Case Report
- Species:
- dog
Plain-English summary
A dog with large, non-healing bite wounds was treated with a special 3D matrix made from fibrin glue and genetically modified stem cells. This innovative treatment helped the dog's body create new blood vessels and heal the wounds more effectively. After applying the bioactive matrix, the dog's wounds showed significant improvement, and the healing process was successful. This case suggests that this new approach could be beneficial for treating serious skin injuries in dogs and potentially other animals in the future.
People also search for: dog skin wound treatment · healing dog bite wounds · bioactive matrix for dog wounds · stem cell therapy for dogs
Abstract
Objectives: Large full-thickness skin defects represent a serious veterinary problem. Methods: We have developed novel bioactive 3D-matrixes based on fibrin glue Tissucol (Baxter), containing the combination of the adenoviral constructs with genes vascular endothelial growth factor 165 (VEGF165) and fibroblast growth factor two (FGF2; construct Ad5-VEGF165 + Ad5-FGF2) or multipotent mesenchymal stem cells, genetically modified with these constructs. Results: In vitro studies confirmed the biosynthesis of VEGF165 and FGF2 mRNA in the transduced cells. Ad5-VEGF165 + Ad5-FGF2- transduced multipotent mesenchymal stem cells showed an enhanced capacity to form capillary-like tubes in vitro. Bioactive 3D-matrix application enhanced granulation tissue formation and epithelialization of non-healing, large bite wounds in a dog. Successful wound healing was observed with a positive clinical outcome for the canine patient. This research and application of regenerative gene therapy alongside a novel bioactive 3D-matrix shows promising clinical applications for the future in both dogs and other mammals including humans.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/30931318