Peer-reviewed veterinary case report
Chemotherapy and second surgery for dog gut cancer treatment
By Stanclift, Rebecca M & Gilson, Stephen D·Published in Journal of the American Veterinary Medical Association·2004·Sonora Veterinary Specialists, United States·View original on PubMed →
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Original publication title: Use of cisplatin, 5-fluorouracil, and second-look laparotomy for the management of gastrointestinal adenocarcinoma in three dogs.
- Species:
- dog
Plain-English summary
Three dogs with advanced gastrointestinal cancer were treated with surgery to remove the tumors, followed by chemotherapy using cisplatin and 5-fluorouracil. After the initial treatment, a second surgery was performed to check for any remaining cancer cells. This approach, while not commonly used in veterinary medicine, showed promise in accurately identifying any leftover cancer. The dogs underwent these treatments to manage their condition, and while the study suggests this method could be beneficial, it highlights the need for careful consideration due to costs and risks involved.
People also search for: dog gastrointestinal cancer treatment · cisplatin for dogs cancer · chemotherapy for dog adenocarcinoma
Abstract
Three dogs with advanced-stage adenocarcinoma of the gastrointestinal tract were treated by use of resection, adjuvant chemotherapy with cisplatin and 5-fluorouracil, and second-look laparotomy (SLL). In combination with histologic examination of biopsy specimens obtained during the procedure, SLL is the most accurate diagnostic procedure for identification of residual or recurrent microscopic or macroscopic abdominal neoplasia; however, to the authors' knowledge, there are no reports of its clinical use in the field of veterinary oncology. This lack of clinical use in animals is likely because of factors such as cost, procedure-associated risks perceived by the owners and veterinarians, lack of data to define proper clinical application, and, perhaps to some degree, an entrenched belief that treatment of advanced stage cancer in animals is inappropriate. Nevertheless, the use of SLL should be considered for evaluation of abdominal tumors or intra-abdominal metastases in dogs that appear to be in complete clinical remission near or at the anticipated completion of chemotherapy (especially if effective second-line chemotherapy protocols are available) or when secondary cytoreduction might be beneficial.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15552318/