Peer-reviewed veterinary case report
How to find brain lesions in dogs and cats using MRI
By Merhof, K et al.·Published in Journal of veterinary internal medicine·2014·Department of Clinical Veterinary Medicine·View original on PubMed →
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Original publication title: Use of contrast-enhanced fluid-attenuated inversion recovery sequence to detect brain lesions in dogs and cats.
Plain-English summary
Researchers looked at whether a special type of brain scan called contrast-enhanced FLAIR (ceFLAIR) could find more brain problems in dogs and cats than other standard scans. They studied 129 pets, including 108 dogs and 21 cats, who were getting MRI scans of their heads. They found a total of 83 brain lesions (or problems) across 51 of the pets, with ceFLAIR detecting some lesions that the other scans missed, but overall, it didn't find more lesions than the other methods combined. The study concluded that using ceFLAIR doesn't really help in finding brain issues better than the standard scans, so it's not recommended for routine use in pets suspected of having brain problems.
Abstract
BACKGROUND: The diagnostic value of a contrast-enhanced T2-weighted FLAIR sequence (ceFLAIR) in brain imaging is unclear. HYPOTHESIS/OBJECTIVES: That the number of brain lesions detected with ceFLAIR would be no greater than the sum of lesions detected with nFLAIR and ceT1W sequence. ANIMALS: One hundred and twenty-nine animals (108 dogs and 21 cats) undergoing magnetic resonance imaging (MRI) of the head between July 2010 and October 2011 were included in the study. METHODS: A transverse ceFLAIR was added to a standard brain MRI protocol. Presence and number of lesions were determined based on all available MRI sequences by 3 examiners in consensus and lesion visibility was evaluated for nFLAIR, ceFLAIR, and ceT1W sequences. RESULTS: Eighty-three lesions (58 intra-axial and 25 extra-axial) were identified in 51 patients. Five lesions were detected with nFLAIR alone, 2 with ceT1W alone, and 1 with ceFLAIR alone. Significantly higher numbers of lesions were detected using ceFLAIR than nFLAIR (76 versus 67 lesions; P = 0.04), in particular for lesions also detected with ceT1W images (53 versus 40; P =.01). There was no significant difference between the number of lesions detected with combined nFLAIR and ceT1W sequences compared to those detected with ceFLAIR (82 versus 76; P =.25). CONCLUSION AND CLINICAL IMPORTANCE: Use of ceFLAIR as a complementary sequence to nFLAIR and ceT1W sequences did not improve the detection of brain lesions and cannot be recommended as part of a routine brain MRI protocol in dogs and cats with suspected brain lesions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24962604/