Peer-reviewed veterinary case report
Use of Direct Current Electroretinography for Analysis of Retinal Pigment Epithelium Function in Mouse Models.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2018
- Authors:
- Yu, Minzhong & Peachey, Neal S
- Affiliation:
- Department of Ophthalmic Research · United States
Abstract
A monolayer of pigmented epithelial cells, the retinal pigment epithelium (RPE), supports photoreceptor function in many ways. Consistent with these roles, RPE dysfunction underlies a number of hereditary retinal disorders. To monitor RPE function in vivo models for these conditions, we adapted an electroretinographic (ERG) technique based on direct current amplification (DC-ERG). This chapter describes the main features of this approach and its application to mouse models involving the RPE.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29564784/