Peer-reviewed veterinary case report
Horse with severe colitis and inflammation treated with hemoperfusion
By Hobbs, Kallie J et al.Ā·Published in Journal of veterinary internal medicineĀ·2024Ā·Department of Clinical Sciences, United StatesĀ·View original on PubMed ā
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Original publication title: Use of extracorporeal hemoperfusion therapy in an adult horse with Clostridioides difficile colitis and severe systemic inflammatory response syndrome.
- Species:
- horse
Plain-English summary
An 8-year-old American Quarter Horse gelding was brought in with severe symptoms including rapid breathing, high heart rate, fever, and changes in gum color due to Clostridioides difficile colitis, which caused a serious inflammatory response. Because the horse also had kidney issues, traditional anti-inflammatory treatments couldn't be used safely. Instead, he received a specialized treatment called extracorporeal hemoperfusion therapy twice within two days, which helped stabilize his condition temporarily. Unfortunately, the horse was euthanized four days later due to laminitis, a painful hoof condition.
People also search for: horse colitis treatment Ā· C. difficile in horses Ā· extracorporeal hemoperfusion for horses
Abstract
An 8-year-old American Quarter Horse gelding was treated with extracorporeal hemoperfusion (HP) therapy for treatment of Clostridioides difficile (C. difficile) colitis-induced systemic inflammatory response syndrome (SIRS). The gelding developed C. difficile associated peracute colitis and severe SIRS as evidenced by a positive fecal C. difficile PCR and tachypnea, tachycardia, fever, neutropenia, altered mucous membrane color, and hyperlactatemia. Concurrent acute kidney injury in the horse limited the use of routine anti-inflammatory and anti-lipopolysaccharide treatments, including flunixin meglumine and polymyxin B, because of potential for nephrosis. Extracorporeal HP therapy was performed twice within 48 hours of the onset of severe SIRS during which the horse's physical examination variables stabilized. The horse was euthanized after 4 days because of laminitis. These findings support further investigation of extracorporeal HP therapy as an adjunctive treatment for severe SIRS/sepsis in horses.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39122666/