Peer-reviewed veterinary case report
Hyaluronidase treatment helps dogs recover from chemotherapy leaks
By Spugnini, Enrico P·Published in Journal of the American Veterinary Medical Association·2002·Regina Elena Cancer Institute, Italy·View original on PubMed →
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Original publication title: Use of hyaluronidase for the treatment of extravasation of chemotherapeutic agents in six dogs.
- Species:
- dog
Plain-English summary
Six dogs experienced swelling and tissue damage after chemotherapy drugs leaked out of their veins during treatment. To help, veterinarians injected a medication called hyaluronidase directly into the affected area. This treatment was repeated weekly until the dogs showed improvement, and all of them recovered within six weeks with minimal lasting damage. Hyaluronidase proved to be a safe and effective way to manage the harmful effects of these chemotherapy leaks, which can otherwise lead to serious complications.
People also search for: dog chemotherapy side effects · hyaluronidase for dog extravasation · treating dog skin damage from chemotherapy
Abstract
Six dogs had perivascular extravasation of antineoplastic agents during IV administration. Treatment with 300 units of hyaluronidase injected locally in the affected site was initiated following the extravasation event. Injections were repeated weekly until signs of toxic effects within the tissues resolved satisfactorily. All dogs recovered within 6 weeks, and residual fibrosis at the extravasation sites most was considered minimal. Many chemotherapeutic agents cause severe cytotoxic reactions when extravasated during cycles of chemotherapy, resulting in tissue necrosis with ulceration and sloughing of skin during the following weeks. Surgical treatments and skin grafting are often necessary to achieve healing. The sequelae of extravasation may result in discontinuation of chemotherapy or euthanasia of the animal. Hyaluronidase appears to be a safe treatment for the adverse effects of extravasation of various chemotherapeutic agents and may be used effectively to reduce the severity of cutaneous toxicosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12458613/