Peer-reviewed veterinary case report
How IV lidocaine helps slow heart rate from dexmedetomidine in dogs
By Tisotti, Tainor et al.·Published in Veterinary anaesthesia and analgesia·2021·Department of Clinical Studies, Canada·View original on PubMed →
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Original publication title: Use of intravenous lidocaine to treat dexmedetomidine-induced bradycardia in sedated and anesthetized dogs.
- Species:
- dog
Plain-English summary
A group of six Beagle dogs experienced a slow heart rate (bradycardia) after receiving a sedative called dexmedetomidine. To address this, the veterinarians administered intravenous lidocaine, which successfully increased the dogs' heart rates and improved their overall heart function. This treatment showed that lidocaine can effectively counteract the heart rate-lowering effects of dexmedetomidine in dogs.
People also search for: dog bradycardia treatment · dexmedetomidine side effects in dogs · lidocaine for dog heart rate issues
Abstract
OBJECTIVE: To assess cardiopulmonary function in sedated and anesthetized dogs administered intravenous (IV) dexmedetomidine and subsequently administered IV lidocaine to treat dexmedetomidine-induced bradycardia. STUDY DESIGN: Prospective, randomized, crossover experimental trial. ANIMALS: A total of six purpose-bred female Beagle dogs, weighing 9.1 ± 0.6 kg (mean ± standard deviation). METHODS: Dogs were randomly assigned to one of three treatments: dexmedetomidine (10 μg kgIV) administered to conscious (treatments SED1 and SED2) or isoflurane-anesthetized dogs (end-tidal isoflurane concentration 1.19 ± 0.04%; treatment ISO). After 30 minutes, a lidocaine bolus (2 mg kg) IV was administered in treatments SED1 and ISO, followed 20 minutes later by a second bolus (2 mg kg) and a 30 minute lidocaine constant rate infusion (L-CRI) at 50 (SED1) or 100 μg kgminute(ISO). In SED2, lidocaine bolus and L-CRI (50 μg kgminute) were administered 5 minutes after dexmedetomidine. Cardiopulmonary measurements were obtained after dexmedetomidine, after lidocaine bolus, during L-CRI and 30 minutes after discontinuing L-CRI. A mixed linear model was used for comparisons within treatments (p < 0.05). RESULTS: When administered after a bolus of dexmedetomidine, lidocaine bolus and L-CRI significantly increased heart rate and cardiac index, decreased mean blood pressure, systemic vascular resistance index and oxygen extraction ratio, and did not affect stroke volume index in all treatments. CONCLUSION AND CLINICAL RELEVANCE: Lidocaine was an effective treatment for dexmedetomidine-induced bradycardia in healthy research dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33485784/