Peer-reviewed veterinary case report
Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: lessons from a murine retrovirus-induced AIDS model.
- Journal:
- Journal of virology
- Year:
- 2014
- Authors:
- O'Connor, Megan A & Green, William R
- Affiliation:
- Department of Microbiology and Immunology · United States
- Species:
- rodent
Abstract
Interferon regulatory factor (IRF) regulation of the type I interferon response has not been extensively explored in murine retroviral infections. IRF-3(-/-) and select IRF-3/7(-/-) mice were resistant to LP-BM5-induced pathogenesis. However, further analyses strongly suggested that resistance could be attributed to strain 129-specific contamination of the known retrovirus resistance gene Fv1. Therefore, caution should be taken when interpreting phenotypes observed in these knockout mice, as strain 129-derived genetic polymorphisms may explain observed differences.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24335302/