Peer-reviewed veterinary case report
Using c-kit mutation to track mast cell tumor spread in 2 dogs
By Zavodovskaya, Regina et al.·Published in Journal of veterinary internal medicine·2004·Department of Surgical and Radiological Sciences, United States·View original on PubMed →
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Original publication title: Use of kit internal tandem duplications to establish mast cell tumor clonality in 2 dogs.
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog and a 9-year-old Labrador were diagnosed with multiple skin tumors called mast cell tumors (MCT) that appeared over 1-2 years. The veterinarians used a specific genetic test to confirm that these tumors were not new growths but rather recurrences of the same original tumor. This means the tumors were genetically identical and originated from the same source. Understanding this helped the vets determine the best treatment approach for these dogs, which may include surgery or other therapies to manage the tumors effectively.
People also search for: dog skin tumors treatment · mast cell tumor in dogs · recurrent mast cell tumor in dogs
Abstract
Mast cell tumor (MCT) is one of the most common tumors of dogs. Some affected dogs develop multiple cutaneous tumors in various locations over months to years. In these cases, it is not clear whether the tumors have arisen de novo, or if each tumor represents a recurrence of the previously excised original tumor (ie, distant metastasis). We used the presence of an internal tandem duplication (ITD) in c-kit to demonstrate that in 2 dogs with recurrent cutaneous MCT that had developed over 1-2 years, each recurrent MCT tumor possessed an identical ITD when compared to the original MCT, indicating that the multiple tumors were clonal in origin. This study demonstrates that similar to the situation in humans, specific somatic mutations identified in oncogenes found in canine neoplasms can be used to provide evidence of tumor clonality.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15638281/