Peer-reviewed veterinary case report
Use of lufenuron as a treatment for fungal endometritis in four mares.
- Journal:
- Journal of the American Veterinary Medical Association
- Year:
- 2002
- Authors:
- Hess, Milan B et al.
- Affiliation:
- Department of Large Animal Clinical Sciences · United States
- Species:
- horse
Plain-English summary
In a study involving four female horses, researchers tested a treatment called lufenuron for a fungal infection in the uterus, known as fungal endometritis, which can cause infertility. The treatment involved washing out the uterus with a solution containing lufenuron mixed with sterile salt water. They checked the effectiveness of the treatment by looking at cell samples and growing cultures from the uterus, as well as monitoring the horses' ability to reproduce afterward. Fungal endometritis can be hard to treat and often comes back, but in this case, the lufenuron treatment successfully cleared the infection in all four mares.
Abstract
Lufenuron, a benzoylphenyl urea derivative, was evaluated as a treatment for endometrial fungal infections in 4 mares. Intrauterine lavage was performed with lufenuron suspended in sterile saline (0.9% NaCl) solution. Cytologic evaluation and fungal culture of the endometrium, as well as subsequent reproductive performance, were used to monitor efficacy of this treatment. Fungal endometritis in mares is associated with infertility. Treatment is often ineffective and costly, and recurrence following treatment is not uncommon. Intrauterine infusions of lufenuron were effective in eliminating fungal endometritis in the 4 mares of this report.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/12118592/