Peer-reviewed veterinary case report
Mycophenolate mofetil helps severe myasthenia gravis in dogs
By Abelson, Amanda L et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2009·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Use of mycophenolate mofetil as a rescue agent in the treatment of severe generalized myasthenia gravis in three dogs.
- Species:
- dog
Plain-English summary
Three dogs with severe muscle weakness and regurgitation due to myasthenia gravis (a condition affecting muscle control) were treated with a medication called mycophenolate mofetil (MMF). Initially, they received another medication and supportive care, but when that didn't work, they were given IV MMF. Remarkably, all three dogs showed improvement within 48 hours and were later switched to oral MMF after their regurgitation stopped. All dogs recovered well without any side effects from the treatment.
People also search for: dog myasthenia gravis treatment · mycophenolate mofetil for dogs · dog regurgitation causes
Abstract
OBJECTIVE: To describe the use of IV and oral mycophenolate mofetil (MMF) as adjunctive therapy in 3 dogs with severe generalized myasthenia gravis. CASE SERIES SUMMARY: Three dogs suffering from severe generalized myasthenia gravis as confirmed by acetylcholine antibody titers were treated with MMF as part of their treatment regimens. All 3 dogs had radiographic evidence of megaesophagus and suffered from severe regurgitation. Each dog was initially treated with pyridostigmine and supportive agents. When clinical remission was not achieved, IV MMF was administered to all dogs. Signs of clinical remission were apparent within 48 hours and all dogs were later maintained on oral MMF following resolution of regurgitation. NEW OR UNIQUE INFORMATION PROVIDED: This is the first report of the use of IV MMF as adjunctive treatment in dogs with severe generalized myasthenia gravis. Outcome was favorable in all 3 dogs and no adverse effects were noted from the MMF.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25164637/