Peer-reviewed veterinary case report
Octreotide treatment for protein-losing gut disease in dogs
By Jablonski, Sara A et al.·Published in Journal of veterinary internal medicine·2024·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Use of octreotide for the treatment of protein-losing enteropathy in dogs: Retrospective study of 18 cases.
- Species:
- dog
Plain-English summary
Eighteen dogs with protein-losing enteropathy (PLE), a condition that causes severe protein loss through the intestines, were treated with a medication called octreotide after standard treatments failed. Most of these dogs had a specific type of PLE related to intestinal lymphangiectasia. While some dogs experienced side effects, the majority tolerated the treatment well, and about half showed improvement in their symptoms. This suggests that octreotide might be a helpful option for dogs with PLE that do not respond to typical therapies.
People also search for: dog protein-losing enteropathy treatment · octreotide for dogs · dog intestinal lymphangiectasia symptoms
Abstract
BACKGROUND: More than 50% of dogs with protein-losing enteropathy (PLE) fail to respond to standard therapies. Octreotide, a somatostatin analogue, is used in cases of intestinal lymphangiectasia (IL) in humans with some success. OBJECTIVES: Describe the use of octreotide in dogs with PLE including reason for and details of prescription, adverse effects, and apparent response. ANIMALS: Eighteen dogs with PLE, 13 with histopathology available. Ninety-two percent (12/13) had IL diagnosed on biopsy. All 13 dogs had intestinal inflammatory infiltrates noted. METHODS: Multicenter, retrospective, descriptive study. Cases were volunteered for inclusion by individual attending veterinarians who reported the use of octreotide in cases of PLE. RESULTS: In 16/18 (89%) cases octreotide was prescribed to PLE dogs with a clinical suspicion or confirmed diagnosis of IL that were refractory to standard therapies. Median serum albumin at the time of octreotide prescription was 1.7 g/dL (range, 1.0-3.1 g/dL). The median dose of octreotide prescribed was 20 μg/kg, SQ, daily with a range of 4-39 μg/kg, SQ, daily. Adverse effects were noted in 3/18 (17%, 95% CI [4%, 41%]) of dogs; discontinuation of the drug was necessary in 1 dog. Improvement in clinical signs was noted in 6/12 (50%, 95% CI [21%, 79%]). CONCLUSIONS AND CLINICAL IMPORTANCE: Octreotide was most commonly prescribed to dogs with PLE and suspected or confirmed IL that had failed to respond to standard therapies. Though a benefit to PLE dogs cannot be confirmed, octreotide was well tolerated by the majority of dogs at the doses prescribed in this study.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38038236/