Peer-reviewed veterinary case report
Oral paclitaxel treatment for bladder tumors in dogs
By Chae, Hyung-Kyu et al.·Published in The Journal of veterinary medical science·2020·Department of Veterinary Clinical Science, South Korea·View original on PubMed →
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Original publication title: Use of oral paclitaxel for the treatment of bladder tumors in dogs.
- Species:
- dog
Plain-English summary
A group of four dogs with bladder tumors or prostate cancer were treated with an oral medication called paclitaxel. While the dogs experienced some mild side effects, like a drop in white blood cell count, some showed positive changes, such as a reduction in tumor size and improvement in their symptoms. Although the tumors continued to progress, the treatment indicated that oral paclitaxel could be a potential option for dogs with these types of cancer. More research is needed, but this case suggests it might help some pets.
People also search for: dog bladder tumor treatment · paclitaxel for dogs cancer · prostate cancer in dogs symptoms
Abstract
An oral paclitaxel formulation that overcomes the hypersensitivity reaction of paclitaxel has been evaluated for safety and efficacy in humans, but not in dogs. We present the first case report on the use of oral paclitaxel in dogs. In this study, oral paclitaxel was well-tolerated in four dogs with either transitional cell carcinoma or prostate cancer; adverse effects were limited to mild neutropenia. Each of the dogs had progressive disease at the end, but clinical responses, including changes in mass size and improvement of clinical symptoms, were confirmed in some of the animals following oral paclitaxel chemotherapy. Although this study is somewhat limited by a small sample size, it suggests that oral paclitaxel may be a chemotherapeutic option for malignant tumors in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32249251/