Peer-reviewed veterinary case report
Pentoxifylline improves sperm quality in dogs with low sperm count
By Cicirelli, Vincenzo et al.·Published in Veterinary medicine and science·2026·Department of Veterinary Medicine, Italy·View original on PubMed →
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Original publication title: Use of Pentoxifylline to Improve Seminal Parameters in Dogs.
- Species:
- dog
Plain-English summary
A group of male dogs with low sperm counts (oligospermic dogs) received an oral treatment of pentoxifylline to see if it could improve their semen quality. After taking the medication, the dogs showed a significant increase in both sperm concentration and movement, which are important for fertility. This suggests that pentoxifylline could be a helpful option for male dogs struggling with fertility issues.
People also search for: dog low sperm count treatment · pentoxifylline for dogs · improving dog semen quality
Abstract
OBJECTIVE: The study aimed to evaluate the effect of a one-shot oral administration of pentoxifylline on semen parameters in normospermic and oligospermic dogs. METHODS: Twenty-nine dogs were categorized as normospermic or oligospermic based on baseline sperm concentration. After 10 days from the first semen evaluation, each dog received 10 mg/kg of pentoxifylline orally, given 40 min prior to ejaculation. Semen was evaluated using a Computer-Assisted Sperm Analysis (CASA) system and Eosin-Nigrosin staining for vitality. RESULTS: Compared with baseline, pentoxifylline treatment resulted in a statistically significant increase in sperm concentration and progressive motility (p < 0.01), most notably in oligospermic dogs. CONCLUSION AND CLINICAL SIGNIFICANCE: These findings highlight the beneficial effects of pentoxifylline and confirm its potential as an adjunct therapy for improving semen quality in subfertile male dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41965913/