Peer-reviewed veterinary case report
Improving radiation dose uniformity in dog nasal tumor treatment
By Pruitt, Amy F & Thrall, Donald E·Published in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2004·Department of Molecular Biomedical Sciences, United States·View original on PubMed →
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Original publication title: Use of photon fields with noncoincident isocenters to improve homogeneity of dose distribution.
- Species:
- dog
Plain-English summary
Eight dogs with nasal tumors were treated using a new radiation technique that involved using different targeting points (noncoincident isocenters) to improve how the radiation was distributed. This method allowed for a higher dose to the tumor while reducing exposure to surrounding healthy tissue, like the mandible, which can suffer side effects from radiation. The results showed that the dogs received better treatment for their tumors without increasing the risk of damage to nearby structures. This approach could lead to more effective and safer radiation therapy for dogs with similar conditions.
People also search for: dog nasal tumor treatment · radiation therapy for dogs · canine cancer radiation side effects
Abstract
To compare changes in dose distribution in irregularly shaped volumes treated using fields with noncoincident isocenters compared with fields with coincident isocenters. The hypothesis was that use of fields with noncoincident isocenters would result in improved homogeneity of dose distribution. We chose to test the hypothesis in canine nasal tumors because of the increased dorsoventral thickness of the caudal compared with the rostral nasal cavity. Computed tomography images from eight dogs with nasal tumors were selected. A tissue-contouring program was used to outline contours, including the mandible as a normal tissue structure and the planning target volume (PTV), divided into a rostral and caudal volume. A traditional computerized treatment plan consisting of two parallel-opposed fields was constructed for each dog. A second treatment plan using a third caudally located field having a different isocenter was constructed for comparison. Dose-volume histograms were generated and compared for each contoured structure in both plans. In all dogs the use of noncoincident fields resulted in increased dose to the ethmoid region through the caudal field. Minimum dose in the caudal tumor PTV increased as well. At the same time, dose delivered to the mandible, prone to develop significant side effects, was lower in all dogs with the use of noncoincident fields, as it was possible to reduce the dose delivered from the ventral field. Use of photon fields with noncoincident isocenters can improve the dose distribution in irregularly shaped volumes in comparison with fields with coincident isocenters. Improved tumor dose distribution was achieved with the addition of a smaller field having a different isocenter.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15487573/