Peer-reviewed veterinary case report
Pimobendan treatment for heart failure in dogs
By Fuentes, Virginia Luis·Published in The Veterinary clinics of North America. Small animal practice·2004·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
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Original publication title: Use of pimobendan in the management of heart failure.
- Species:
- dog
Plain-English summary
A dog with heart failure was treated with pimobendan, a medication that helps improve heart function. This drug works by making the heart pump more effectively and reducing strain on the heart. Clinical studies have shown that pimobendan can lead to better heart performance and improved exercise ability in dogs. It appears to be as effective, if not more so, than traditional treatments like ACE inhibitors. As a result, pimobendan is becoming an important option for managing heart disease in dogs.
People also search for: dog heart failure treatment · pimobendan for dogs · heart medication for dogs
Abstract
Pimobendan is an oral inodilator compound available in many countries for use in canine heart failure. It combines calcium-sensitizing effects with PDE III inhibition, resulting in positive inotropic effects and veno- and ergic signal transduction pathway in the failing heart, the calcium-sensitizing effects may assume greater importance in patients with heart failure. Clinical studies in human patients have shown sustained improvement in hemodynamics and exercise tolerance, with favorable neurohormonal effects. One study showed a nonsignificant trend toward increased mortality [20], but proarrhythmic effects have not ben observed. Studies in naturally occurring canine heart failure suggest that pimobendan's effects are at least comparable to those of ACE inhibitors, if not superior. Pimobendan is likely to play an increasing role in the future in the treatment of canine heart disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15325474/