Peer-reviewed veterinary case report
Dog with aortic blood clot treated with alteplase after protein loss
By Clare, A C & Kraje, B J·Published in Journal of the American Veterinary Medical Association·1998·Department of Small Animal Medicine, United States·View original on PubMed →
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Original publication title: Use of recombinant tissue-plasminogen activator for aortic thrombolysis in a hypoproteinemic dog.
- Species:
- dog
Plain-English summary
A 5.25-year-old male Yorkshire Terrier was brought in with hind limb paralysis and cold legs, indicating a serious blood flow issue. The vet discovered a blood clot in the dog's aorta, likely caused by a condition that made the dog lose protein. They treated him with a medication called alteplase, which helped dissolve the clot without causing major bleeding problems. This treatment was effective, and the dog's condition improved, restoring blood flow to his hind legs.
People also search for: dog hind limb paralysis treatment · Yorkshire Terrier blood clot · alteplase for dogs
Abstract
A 5.25-year-old male Yorkshire Terrier was evaluated for suspected thrombosis of the distal portion of the aorta following protein-losing enteropathy. Hind limb paralysis was evident, extremities were hypothermic, and femoral pulses were not palpable. A thrombus was found in the distal portion of the aorta using Doppler ultrasonography. Enteropathy-induced loss of albumin and antithrombin III was the suspected cause of hypercoagulability in this dog. Alteplase, a recombinant tissue-plasminogen activator, was used to recanalize the distal portion of the aorta without inducing clinically evident systemic fibrinogenolysis. Alteplase is a fibrin-specific activator of plasminogen and may be safer and more efficacious than conventional streptokinase treatment. Current information on use in thromboembolic disease in human beings suggests that administration of alteplase as a bolus leads to earlier arterial patency and reduced risk of hemorrhage.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9491162/