Peer-reviewed veterinary case report
Dog with chylothorax treated using clot-busting drug after vein clot
By Bliss, Stuart P et al.·Published in Journal of the American Animal Hospital Association·2002·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Use of recombinant tissue-plasminogen activator in a dog with chylothorax secondary to catheter-associated thrombosis of the cranial vena cava.
- Species:
- dog
Plain-English summary
A 4-year-old male Maltese was brought in with fluid buildup in the chest (chylothorax) after developing a blood clot in the large vein near the heart following a catheter placement for surgery. The veterinarian used a special medication called recombinant tissue-plasminogen activator (t-PA) to dissolve the clot. This treatment successfully reduced the size of the clot and quickly resolved the fluid buildup in the dog's chest. However, the dog experienced some bleeding at the catheter sites, which limited the amount of medication that could be given.
People also search for: dog chylothorax treatment · Maltese blood clot symptoms · t-PA for dog thrombosis
Abstract
A 4-year-old, castrated male Maltese developed cranial vena caval thrombosis and chylothorax following central venous catheterization for treatment of postoperative sepsis. Vena caval thrombolysis was attempted using recombinant human tissue-plasminogen activator (t-PA). Thrombolytic therapy led to an acute reduction in the size of the caval thrombus and was followed by prompt resolution of the chylothorax. Hemorrhage at the entry sites of a jugular catheter and esophagostomy tube placed at the time of treatment was a dose-limiting complication of t-PA therapy in this dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12220027/