Peer-reviewed veterinary case report
Dog with chronic hepatitis treated with ursodeoxycholic acid improved
By Meyer, D J et al.·Published in Journal of veterinary internal medicine·1997·Department of Physiological Sciences, United States·View original on PubMed →
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Original publication title: Use of ursodeoxycholic acids in a dog with chronic hepatitis: effects on serum hepatic tests and endogenous bile acid composition.
- Species:
- dog
Plain-English summary
A dog with chronic hepatitis was experiencing severe liver issues and was treated with a medication called ursodeoxycholic acid (UDCA). After just two weeks of daily treatment, the dog became more active and started eating better. Blood tests showed significant improvement in liver function and a decrease in harmful bile acids. These positive effects lasted for about six months, suggesting that UDCA could be a helpful option for dogs with similar liver problems.
People also search for: dog chronic hepatitis treatment · ursodeoxycholic acid for dogs · dog liver disease symptoms
Abstract
A dog with severe cholestasis secondary to chronic hepatitis was treated with ursodeoxycholic acid (UDCA) PO. After 2 weeks of daily treatment, the dog was more active and had an improved appetite. Monthly serum biochemical determinations and analysis of individual bile acid profiles documented improvement in hepatobiliary tests and a marked reduction in the concentrations of potentially hepatotoxic endogenous bile acids. These effects were maintained for approximately 6 months. The findings in this dog are similar to those reported for human patients treated with UDCA and provide preliminary evidence in support of its continued evaluation in the treatment of cholestatic liver disease in the dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9183773/