Peer-reviewed veterinary case report
How well cefovecin works for dog skin infections with mecA bacteria
By Iyori, Keita et al.·Published in Veterinary dermatology·2013·Tokyo University of Agriculture and Technology, Japan·View original on PubMed →
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Original publication title: Usefulness of cefovecin disk-diffusion test for predicting mecA gene-containing strains of Staphylococcus pseudintermedius and clinical efficacy of cefovecin in dogs with superficial pyoderma.
- Species:
- dog
Plain-English summary
A group of dogs with skin infections caused by Staphylococcus pseudintermedius were treated with cefovecin, an antibiotic commonly used for skin issues. Researchers found that a specific test could predict whether the bacteria would be resistant to cefovecin, which helped determine how effective the treatment would be. Dogs with bacteria that were susceptible to the antibiotic showed significant improvement in their skin condition after 14 days, while those with resistant strains did not improve as much. This information can help vets choose the best treatment for dogs with superficial pyoderma.
People also search for: dog skin infection treatment · cefovecin for dog pyoderma · antibiotic resistance in dogs
Abstract
BACKGROUND: Cefovecin has been widely used to treat skin infections in dogs. The relationship of the cefovecin disk-diffusion test results to the presence of the mecA gene and the clinical efficacy of cefovecin have not been fully evaluated. HYPOTHESIS/OBJECTIVES: To determine the usefulness of an in vitro cefovecin disk-diffusion test in predicting the presence of the mecA gene in Staphylococcus pseudintermedius, as well as the in vivo efficacy of cefovecin therapy in dogs with superficial pyoderma. METHODS: Twenty-six S. pseudintermedius strains isolated from 22 dogs with pyoderma were used. In vitro disk-diffusion test results of cefovecin were compared with agar-dilution test results, the presence of the mecA gene, and the improvement in clinical scores of dogs with superficial pyoderma at 14 days post treatment. RESULTS: There was a significant linear correlation (r = -0.83) between the diameter of the obvious zone of inhibition by disk diffusion and the minimal inhibitory concentration for cefovecin (P < 0.0001). Receiver operating characteristic analysis revealed that zone diameters between 25 and 27 mm exhibited better sensitivity (92.9%) and specificity (100.0%) for detection of strains carrying the mecA gene. The mean improvement in clinical scores in dogs carrying cefovecin-resistant strains was significantly lower than in dogs carrying cefovecin-susceptible strains (P < 0.01). CONCLUSIONS AND CLINICAL IMPORTANCE: The cefovecin disk-diffusion test with a cut-off value estimated in this study was valuable for predicting mecA gene carriage in S. pseudintermedius, as well as the in vivo efficacy of cefovecin therapy in dogs with superficial pyoderma caused by S. pseudintermedius.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23331693/