Peer-reviewed veterinary case report
Using fast-scan cyclic voltammetry to evaluate striatal dopamine release elicited by subthalamic nucleus stimulation.
- Journal:
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
- Year:
- 2009
- Authors:
- Covey, Dan P & Garris, Paul A
- Affiliation:
- School of Biological Sciences and Department of Chemistry · United States
- Species:
- rodent
Abstract
Deep brain stimulation (DBS), an effective neurosurgical therapy for Parkinson's disease (PD), may act via eliciting neurotransmitter release. However, the precise relationships between DBS and neurotransmitter release are not established. One issue in these studies may be analytical limitations of microdialysis and positron emission tomography, the primary measurement technologies employed. Limitations may be overcome by microsensors, which exhibit improved temporal and spatial resolution. Here we assess fast-scan cyclic voltammetry (FSCV) at a carbon-fiber microelectrode (CFM) for monitoring a putative DBS neurotransmitter, dopamine, during stimulation of the subthalamic nucleus (STN), a DBS target for PD. These results, obtained in the anesthetized rat, suggest that real-time microsensors are a suitable approach for testing the neurotransmitter release hypothesis of DBS action.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19964299/