Peer-reviewed veterinary case report
Antibiotic resistance in dogs with eye infections - what to know
By Jinks, Maggie R et al.·Published in Veterinary ophthalmology·2020·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Using minimum inhibitory concentration values of common topical antibiotics to investigate emerging antibiotic resistance: A retrospective study of 134 dogs and 20 horses with ulcerative keratitis.
Plain-English summary
A group of 134 dogs with bacterial ulcerative keratitis (a serious eye infection) was studied to see how effective common topical antibiotics were against the bacteria causing their condition. The most common bacteria found were Staphylococcus, Streptococcus, and Pseudomonas. It was noted that previous use of certain antibiotics (fluoroquinolones) could make these bacteria harder to treat, as they showed increased resistance over time. As a result, veterinarians may need to consider alternative antibiotics for dogs with Staphylococcus infections, especially if they have been treated with fluoroquinolones in the past.
People also search for: dog eye infection treatment · antibiotic resistance in dogs · Staphylococcus eye infection in dogs
Abstract
OBJECTIVES: To identify the minimum inhibitory concentration (MIC) distribution for commonly used topical antibiotics from isolates of dogs and horses with ulcerative bacterial keratitis, and to investigate changes in MIC values over time and following treatment with topical fluoroquinolones. ANIMALS STUDIED: One hundred thirty-four client-owned dogs and 20 client-owned horses with bacterial ulcerative keratitis. PROCEDURE: Minimum inhibitory concentration values for 14 topical antibiotics were reported for canine and equine cases of bacterial ulcerative keratitis between 2013 and 2018. Changes in MIC values over time and after treatment with topical fluoroquinolones were reported. RESULTS: The three most common bacterial genera isolated were Staphylococcus, Streptococcus, and Pseudomonas. Together, these represented 79.4% of canine cases and 77.4% of equine cases. Overall, isolates from horses tended to have lower MIC values, as did Pseudomonas isolates from both dogs and horses, compared to other bacterial genera, especially Staphylococcus spp. The MIC values of erythromycin and trimethoprim sulfa for Staphylococcus spp., and the MIC value of moxifloxacin for Pseudomonas significantly increased over time. Previous topical fluoroquinolone use was associated with a significant increase in the MIC value of ofloxacin in canine and equine Staphylococcus isolates and current topical fluoroquinolone use was associated with significant increases in the MIC values of ciprofloxacin, moxifloxacin, and ofloxacin in canine Staphylococcus isolates. CONCLUSION: Patients previously or currently treated with topical fluoroquinolones, particularly in Staphylococcus infections, may require alternative antibiotics or additional antibiotic classes other than fluoroquinolones. Bacterial culture with MIC susceptibility testing should be highly recommended when a Staphylococcal infection is suspected.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32608547/