Peer-reviewed veterinary case report
Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21.
- Journal:
- Progress in brain research
- Year:
- 2020
- Authors:
- Cannavo, Claudia et al.
- Affiliation:
- Department of Neuromuscular Diseases · United Kingdom
Abstract
People who have Down syndrome are at significantly elevated risk of developing early onset Alzheimer's disease that causes dementia (AD-DS). Here we review recent progress in modeling the development of AD-DS in mouse models. These studies provide insight into mechanisms underlying Alzheimer's disease and generate new clinical research questions. In addition, they suggest potential new targets for disease prevention therapies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32057307/