Peer-reviewed veterinary case report
Monitoring chronic pancreatitis in dogs using DGGR-lipase levels
By Kuzi, Sharon et al.·Published in Journal of veterinary internal medicine·2023·Department of Small Animals Internal Medicine·View original on PubMed →
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Original publication title: Utility of 1,2-o-dilauryl-rac-glycero glutaric acid-(6'-methylresorufin)-ester-lipase for monitoring dogs with chronic pancreatitis.
- Species:
- dog
Plain-English summary
A group of 24 dogs with chronic pancreatitis (CP) were monitored to see how a specific enzyme test (DGGR-lipase) related to their symptoms. The dogs showed varying degrees of illness, with many experiencing mild to moderate symptoms, while others had severe cases. The enzyme levels were higher during emergency visits, indicating possible flare-ups of the condition. Although the enzyme activity was linked to the severity of symptoms, it wasn't very effective at distinguishing between mild and severe cases. Overall, the findings suggest that while this test can help track changes in dogs with CP, it may not be the best tool for assessing how serious the disease is.
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Abstract
BACKGROUND: The utility of 1,2-o-dilauryl-rac-glycero glutaric acid-(6'-methylresorufin)-ester-(DGGR)-lipase activity (DLA) in monitoring clinical progression of chronic pancreatitis (CP) in dogs is unknown. OBJECTIVE: To examine the association of DLA with clinical signs of CP, as assessed by a CP clinical severity score (CPCSS). ANIMALS: Twenty-four dogs. METHODS: This is a retrospective study. Chronic pancreatitis was diagnosed based on clinical signs and DLA > 250 U/L and monitored using CPCSS and DLA. RESULTS: The study included 134 visits (median, 10 visits/dog; range, 2-11). Mild-moderate (CPCSS, 0-3) and severe (CPCSS, ≥4) disease were documented in 94 (70%) and 40 (30%) visits, respectively. In emergency visits (n = 44; 33%) CPCSS (median, 5; range, 0-15) and DLA (median, 534 U/L; range, 63-7133) were higher (P < .001 and P = .003, respectively) than in scheduled ones (n = 90; 67%; median, 1; range, 0-6 and median, 384 U/L; range, 49-3747, respectively). DGGR-lipase activity was associated (P = .009) with the CPCSS, with a lower activity documented in mild-moderate CPCSS (median 391 U/L; range, 49-3747), compared to severe score (median, 558 U/L; range, 63-7133). DGGR-lipase activity was significantly, but weakly, correlated with CPSS (r = 0.233, P = .007). DGGR-lipase activity inefficiently discriminated mild-moderate vs severe CP (area under the receiver operator characteristics curve, 0.64; 95% confidence interval, 0.53-0.75; P = .012), with DLA cutoff of 428 U/L corresponding to sensitivity of 65% and specificity of 63%. CONCLUSIONS AND CLINICAL IMPORTANCE: Increased DLA is associated with emergency revisits in dogs with CP, possibly reflecting acute flare-ups. DGGR-lipase activity was associated with the CPCSS over the follow-ups but could not differentiate disease severity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36785918/