Utility of Animal Models of Pneumonia and Sepsis.

Abstract

Pneumonia remains a leading cause of mortality worldwide. While infectious diseases pose a greater burden in resource-limited regions, pneumonia has the highest incidence and mortality rates among all infectious diseases globally. In the United States, mortality rates due to pneumonia and influenza have shown little improvement over the past 50 years. Sepsis also remains a major global health challenge, with a high incidence and a mortality rate of approximately 20%. Despite significant advancements in medical science, progress in identifying effective therapeutic strategies has been slow.