Peer-reviewed veterinary case report
Vaccine development for large Babesia infections in dogs
By Schetters, T P M et al.·Published in Parassitologia·2007·Parasitology R&D Department, Netherlands·View original on PubMed →
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Original publication title: Vaccination against large Babesia species from dogs.
- Species:
- dog
Plain-English summary
A new vaccine called Nobivac Piro has been developed to protect dogs from serious infections caused by Babesia parasites, which can lead to severe illness. Initial vaccines only provided limited protection, but researchers found that combining antigens from two different Babesia species (B. canis and B. rossi) offered broader immunity. This means that dogs vaccinated with Nobivac Piro are better protected against various strains of these parasites. If you're concerned about Babesia infections in your dog, ask your veterinarian about this new vaccine option.
People also search for: dog Babesia vaccine · symptoms of Babesia in dogs · how to protect dogs from Babesia
Abstract
The original observation of Sibinovic that soluble parasite antigens (SPA) of B. canis could be used to protect dogs against challenge infection formed the starting point for the development of an effective vaccine. With the advent of in vitro cultivation techniques for haemoprotozoan parasites an important tool became available for the commercial production of the vaccine antigens. A first generation vaccine was developed for dogs, but it appeared that the level of protection induced was not complete. In contrast to what was found with the SPA from serum/plasma of infected animals, protection induced with SPA from a single Babesia canis strain protected against a homologous challenge infection only. Further research led to the discovery that a combination of SPA of B. canis and SPA of B. rossi induced a broad spectrum of immunity. This improved vaccine, Nobivac Piro, not only induces protection against heterologous B. canis infection, but also against heterologous B. rossi infection.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17691601/