Peer-reviewed veterinary case report
Vaccine rEGVac protects dogs and sheep from Echinococcus stages
By Pourseif, Mohammad M et al.·Published in Acta tropica·2021·Biomedicine Institute·View original on PubMed →
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Original publication title: Vaccination with rEGVac elicits immunoprotection against different stages of Echinococcus granulosus life cycle: A pilot study.
- Species:
- dog
Plain-English summary
A group of 15 dogs received a new vaccine designed to protect against a parasite called Echinococcus granulosus, which can cause serious health issues. After two doses of the vaccine, the dogs showed a significant increase in protective antibodies, and the number of hydatid cysts (which can develop from the parasite) was reduced by about 85%. This suggests that the vaccine is effective in providing immune protection for dogs against this infection. The results are promising for using this vaccine to help control the spread of the parasite in both dogs and sheep.
People also search for: dog echinococcosis vaccine · dog hydatid cyst treatment · how to prevent Echinococcus in dogs
Abstract
Vaccination against dog-sheep transmission cycle is necessary to control cystic echinococcosis (CE) infection. A multi-epitope multi-antigenic recombinant vaccine was developed-comprising the three putative vaccine antigens EG95, Eg14-3-3 and EgEnolase-was cloned and expressed. In a pilot experiment, the multi-antigen vaccine was assessed in 15 dogs and 15 sheep (five experimental groups and three animals in each group) by two subcutaneous doses 28 days apart. To evaluate the efficacy of the vaccine candidate first immunological analysis were done comprising IgG and IgE antibodies and the cytokine IL-4 in sera of the immunized dogs and sheep. Serum IgG, IgE, and IL-4, in particular in the dogs, were increased after the two rounds of vaccine candidate injection, while the total number of hydatid cysts was reduced (~85.43%). This pilot trial indicated significant immune protection efficacy against E. granulosus especially in dogs, while its efficacy in sheep was not as high as dogs. The multi-antigenic candidate vaccine is proposed as a protective vaccine modality in both dogs and sheep.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33676937/