Peer-reviewed veterinary case report
Vaccine with ospA- and ospB-negative strain cuts Lyme disease in dogs
By LaFleur, Rhonda L et al.·Published in Clinical and vaccine immunology : CVI·2015·Merck Animal Health, United States·View original on PubMed →
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Original publication title: Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease.
- Species:
- dog
Plain-English summary
A group of Beagles was vaccinated with a special strain of Borrelia burgdorferi, the bacteria that causes Lyme disease, to see if it would protect them from ticks. After being exposed to ticks, fewer vaccinated dogs showed signs of infection compared to those that received a placebo. While 90% of the placebo dogs developed joint problems, only 40% of the vaccinated dogs did. This study suggests that this vaccine can significantly reduce the risk of Lyme disease in dogs.
People also search for: Lyme disease vaccine for dogs · Beagle joint problems · how to prevent ticks on dogs
Abstract
Beagles received placebo or ospA- and ospB-negative Borrelia burgdorferi before a tick challenge. A total of 28 (41%) ticks and skin biopsy specimens from each control dog (n = 10) contained B. burgdorferi. In contrast, 12 (19%) ticks recovered from the vaccine recipients (n = 10) were infected (P = 0.0077), and 5 dogs yielded spirochetes from the skin biopsy specimens (P = 0.0325). In addition, 9 (90%) placebo recipients and 4 (40%) vaccine recipients developed joint abnormalities (P = 0.0573). Therefore, vaccination with the ospA- and ospB-negative spirochete provided significant protection against Lyme disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25972405/