Peer-reviewed veterinary case report
Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease.
- Journal:
- Clinical and vaccine immunology : CVI
- Year:
- 2015
- Authors:
- LaFleur, Rhonda L et al.
- Affiliation:
- Merck Animal Health · United States
- Species:
- dog
Abstract
Beagles received placebo or ospA- and ospB-negative Borrelia burgdorferi before a tick challenge. A total of 28 (41%) ticks and skin biopsy specimens from each control dog (n = 10) contained B. burgdorferi. In contrast, 12 (19%) ticks recovered from the vaccine recipients (n = 10) were infected (P = 0.0077), and 5 dogs yielded spirochetes from the skin biopsy specimens (P = 0.0325). In addition, 9 (90%) placebo recipients and 4 (40%) vaccine recipients developed joint abnormalities (P = 0.0573). Therefore, vaccination with the ospA- and ospB-negative spirochete provided significant protection against Lyme disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25972405/