Peer-reviewed veterinary case report
Vaccine potential of an attenuated Pasteurella multocida that expresses only the N-terminal truncated fragment of P. multocida toxin in pigs.
- Journal:
- Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
- Year:
- 2012
- Authors:
- Kim, Taejung et al.
- Affiliation:
- College of Veterinary Medicine · South Korea
Abstract
Previously we described the development of an attenuated Pasteurella multocida mutant that expresses only the N-terminal truncated fragment of P. multocida toxin (N-PMT) and its protective effects in a mouse model. This paper details our evaluation of the vaccine potential of this mutant strain in pigs. Pigs vaccinated with the mutant showed significantly higher rates of antibody induction and lower nasal conchal (turbinate) scores for atrophic rhinitis than controls, which suggests that this mutant strain may be a good candidate for a live attenuated vaccine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22754098/