Peer-reviewed veterinary case report
Dog with muscle disease like human inclusion body myositis
By King, Jason et al.·Published in Acta neuropathologica·2009·Veterinary Medical Teaching Hospital, United States·View original on PubMed →
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Original publication title: Vacuolar myopathy in a dog resembling human sporadic inclusion body myositis.
- Species:
- dog
Plain-English summary
A 11-year-old dog was brought in for chronic and worsening muscle weakness, which made it difficult for him to move normally. After several tests, including muscle biopsies, the vet found signs of a condition similar to a rare human muscle disease called sporadic inclusion body myositis (sIBM). The dog's muscle samples showed abnormal structures and inflammation, indicating both damage and immune response in the muscles. While this condition is not common in dogs, the findings suggest that similar muscle issues can occur in pets. Unfortunately, the abstract does not provide information on the treatment or outcome for this dog.
People also search for: dog muscle weakness treatment · what causes muscle problems in dogs · signs of myopathy in dogs
Abstract
Sporadic inclusion body myositis (sIBM) is the most common myopathy in people over the age of 50 years. While immune-mediated inflammatory myopathies are well documented in dogs, sIBM has not been described. An 11-year-old dog with chronic and progressive neuromuscular dysfunction was evaluated for evidence of sIBM using current pathologic, immunohistochemical and electron microscopic diagnostic criteria. Vacuoles and congophilic intracellular inclusions were identified in cryostat sections of multiple muscle biopsies and immunostained with antibodies against amyloid-beta peptide, amyloid-beta precursor protein, and proteosome 20S of the ubiquitin-proteosome system. Cellular infiltration and increased expression of MHC Class I antigen were observed. Cytoplasmic filamentous inclusions, membranous structures, and myeloid bodies were identified ultrastructurally. These observations constitute the first evidence that both the inflammatory and degenerative features of human sIBM can occur in a non-human species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19718499/