Peer-reviewed veterinary case report
How the 13C-urea breath test detects stomach Helicobacter in dogs
By Kubota, Sanae et al.·Published in The Journal of veterinary medical science·2013·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Value of the 13C-urea breath test for detection of gastric Helicobacter spp. infection in dogs undergoing endoscopic examination.
- Species:
- dog
Plain-English summary
A group of healthy beagles underwent a special breath test to check for a stomach infection caused by Helicobacter bacteria. After being treated with antibiotics and medication for 14 days, the dogs were found to be free of the infection. The study showed that this breath test is effective, with a high success rate in detecting the infection in dogs. This method could help vets diagnose similar issues in other dogs more easily and quickly.
People also search for: dog stomach infection symptoms · Helicobacter treatment for dogs · dog breath test for stomach issues
Abstract
Urea breath test (UBT) using an infrared spectral analyzer is widely used for non-invasive and rapid detection of gastric Helicobacter spp. in human, but not veterinary medicine. The main purposes of this study were to determine the reference range of the UBT in dogs and to evaluate its clinical usefulness. To address the first aim, 6 healthy laboratory beagles were subjected to UBT and upper gastrointestinal endoscopy. Gastric endoscopic biopsy samples from the antrum, corpus and fundus were examined for Helicobacter spp. by polymerase chain reaction (PCR) testing, rapid urease test (RUT), histology and cytology. Amoxicillin, metronidazole and omeprazole were given to infected dogs for 14 days, and dogs that became Helicobacter-negative were used to determine the reference range for UBT. To address the second aim, 32 canine patients underwent UBT before upper gastrointestinal endoscopy, and the sensitivity and specificity of UBT were calculated based on our newly determined reference range using PCR as the gold standard for detection of Helicobacter spp. Initially, all 6 laboratory beagles were infected in all gastric regions and became uninfected after eradication. The mean ± 2 SD UBT value after eradication was 0.6 ± 1.8‰, and the reference range for UBT was determined to be less than 2.5‰. UBT was completed successfully in 27 patients. Using our reference range, UBT displayed 89% (16/18) sensitivity and 89% (8/9) specificity, indicating that UBT was quite useful for the detection of gastric Helicobacter spp. infection in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23558958/