Peer-reviewed veterinary case report
Variable PEEP helps oxygen levels in dogs with lung injury from oleic
By Lanza, F C et al.·Published in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2009·Disciplina de Pneumologia·View original on PubMed →
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Original publication title: Variable positive end-expiratory pressure can maintain oxygenation in experimental acute respiratory distress syndrome induced by oleic acid in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with acute respiratory distress syndrome (ARDS) caused by oleic acid were treated with different breathing support techniques to improve their oxygen levels. The dogs were divided into three groups: one received low variable pressure, another high variable pressure, and the last group received high variable pressure along with a lung recruitment maneuver (a technique to open collapsed airways). The group that received the lung recruitment maneuver showed the best oxygen levels. While there was a drop in heart output after the maneuver, the variable pressure helped maintain oxygen levels effectively.
People also search for: dog breathing problems treatment · ARDS in dogs · lung recruitment maneuver for dogs
Abstract
The use of positive end-expiratory pressure (PEEP) or lung recruitment maneuvers (RM) to improve oxygenation in acute respiratory distress syndrome (ARDS) is used but it may reduce cardiac output (CO). Intermittent PEEP may avoid these complications. Our objective was to determine if variable PEEP compared with constant PEEP is capable of maintaining arterial oxygenation and minimizing hemodynamic alterations with or without RM. Eighteen dogs with ARDS induced by oleic acid were randomized into three equal groups: group 1, low variable PEEP; group 2, high variable PEEP, and group 3, RM + high variable PEEP. All groups were submitted to constant PEEP, followed by variable PEEP (PEEP was increased from 5 to 10 cmH(2)O in group 1, and from 5 to 18 cmH(2)O in the other two groups). PaO(2) was higher in group 3 (356.2 +/- 65.4 mmHg) than in group 1 (92.7 +/- 29.7 mmHg) and group 2 (228.5 +/- 72.4 mmHg), P < 0.05. PaO(2) was maintained during variable PEEP except in group 2 (318.5 +/- 82.9 at constant PEEP to 228.5 +/- 72.4 at variable PEEP). There was a reduction in CO in group 3 after RM (3.9 +/- 1.1 before to 2.7 +/- 0.5 L*min(-1)*(m(2))(-1) after; P < 0.05), but there was not any difference between constant and variable PEEP periods (2.7 +/- 0.5 and 2.4 +/- 0.7 L*min(-1)*(m(2))(-1); P > 0.05. Variable PEEP is able to maintain PaO(2) when performed in combination with RM in dogs with ARDS. After RM, CO was reduced and there was no relevant difference between the variable and constant PEEP periods.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19649399/