Peer-reviewed veterinary case report
Variation in immunogenicity of ruminant pestiviruses as determined by the neutralisation assay.
- Journal:
- Veterinary journal (London, England : 1997)
- Year:
- 2005
- Authors:
- Patel, J R et al.
- Affiliation:
- Intervet UK Ltd. · United Kingdom
Abstract
Immunogenicity in naive three-month-old Friesian bull calves of nine ruminant pestiviruses, three each of type 1 bovine virus diarrhoea virus (BVDV), type 2 BVDV and border disease virus (BDV) was directly compared in reciprocal cross-neutralisation tests using sera obtained eight weeks after intranasal and intravenous inoculation with live virus. Cytopathic (CP) type 1 BVDV strain C86, non-cytopathic (NCP) type 2 BVDV strain 890 and NCP BDV strain V2536/2 were found to elicit significantly broad cross-neutralising antibodies against viruses in other species whereas other virus strains in all three species produced a much more pronounced homologous and/or species specific response. Results are clearly relevant in the selection of strains for vaccines against diseases caused by these successful, economically important ubiquitous viruses.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15848792/