Peer-reviewed veterinary case report
Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia.
- Journal:
- Canadian journal of physiology and pharmacology
- Year:
- 2021
- Authors:
- Badran, Mohammad et al.
- Affiliation:
- Department of Child Health and the Child Health Research Institute · United States
- Species:
- rodent
Abstract
Obstructive sleep apnea (OSA) is a chronic condition characterized by chronic intermittent hypoxia (IH) and is associated with cardiovascular (CVD) and chronic kidney diseases (CKD). Patients with OSA have increased biomarkers of aging such as telomere shortening. We used PCR to report shortened telomere lengths in aortic and renal tissues from mice exposed to 8 weeks of IH. Our data indicate that IH, a hallmark of OSA, accelerates vascular and renal aging that may contribute to OSA-induced CVD and CKD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33951396/