Peer-reviewed veterinary case report
Vascular dysfunction in Hutchinson-Gilford progeria syndrome.
- Journal:
- Trends in molecular medicine
- Year:
- 2025
- Authors:
- Zhao, Yaping et al.
- Affiliation:
- Department of Endocrinology · China
Abstract
Most patients with Hutchinson-Gilford progeria syndrome (HGPS) succumb to cardiovascular disease. Recent studies by Barettino et al., Cardoso et al., and Vakili et al. utilized progeria mouse models to elucidate novel mechanisms by which vascular smooth muscle cell (VSMC) and endothelial cell (EC) dysfunction accelerate the progress of the disease, thus providing directions for the development of new targeted pharmaco-therapies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39741011/