Peer-reviewed veterinary case report
Desmopressin helps urine concentration in dogs with pyometra
By Heiene, Reidun et al.·Published in American journal of veterinary research·2004·Department of Companion Animal Clinical Sciences·View original on PubMed →
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Original publication title: Vasopressin secretion in response to osmotic stimulation and effects of desmopressin on urinary concentrating capacity in dogs with pyometra.
- Species:
- dog
Plain-English summary
A group of dogs with pyometra (a serious uterine infection) had their urine concentration tested before and after surgery. They were also given a medication called desmopressin to see how well it helped them concentrate their urine. While the dogs with pyometra showed some improvement in urine concentration after treatment, it wasn't as effective as in healthy control dogs. This suggests that while their ability to respond to the medication was present, it wasn't as strong as in dogs without the condition.
People also search for: dog pyometra treatment · desmopressin for dogs · dog urine concentration problems
Abstract
OBJECTIVE: To determine vasopressin (VP) secretory capacity during osmotic stimulation and the response to desmopressin treatment in dogs with pyometra and control dogs. ANIMALS: 6 dogs with pyometra before and after ovariohysterectomy and 6 control dogs. PROCEDURE: Urine osmolality (Uosm) was measured during 12 hours. Values measured on the first day defined the basal Uosm pattern. On the second day, dogs were given desmopressin to induce a desmopressin-stimulated Uosm pattern. On day 3, the VP response to osmotic stimulation was examined. RESULTS: Median Uosm on day 1 was 340 mOsm/kg (range, 104 to 1,273 mOsm/kg) and 807 mOsm/kg (range, 362 to 1,688 mOsm/kg) in dogs with pyometra before and after surgery, respectively, and 1,511 mOsm/kg (range, 830 to 1,674 mOsm/kg) in control dogs. Median Uosm during desmopressin treatment was 431 mOsm/kg (range, 168 to 1,491 mOsm/kg) and 1,051 mOsm/kg (range, 489 to 1,051 mOsm/kg) in dogs with pyometra before and after surgery, respectively, and 1,563 mOsm/kg (range, 1,390 to 2,351) in control dogs. In dogs with pyometra, threshold for VP secretion was lower before surgery (median, 340 mOsm/kg; range, 331 to 366 mOsm/kg) than after surgery (median, 358 mOsm/kg; range, 343 to 439 mOsm/kg) or in control dogs (median, 347 mOsm/kg; range, 334 to 360 mOsm/kg). Highest maximum plasma VP values were found in dogs with pyometra. CONCLUSIONS AND CLINICAL RELEVANCE: Dogs with pyometra had increased urine concentration in response to desmopressin but not to the degree of control dogs, whereas VP secretory ability was not reduced.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15077680/