Peer-reviewed veterinary case report
VEGF protein found in dog skin mast cell tumor cells
By Mederle, O et al.·Published in Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2010·Universitatea de Medicină·View original on PubMed →
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Original publication title: VEGF expression in dog mastocytoma.
- Species:
- dog
Plain-English summary
A dog with a skin tumor, specifically a mast cell tumor, was found to have high levels of a protein called VEGF, which is linked to tumor growth. This protein was present in the tumor cells but not in the surrounding inflammatory cells. Unfortunately, despite the findings, the dog passed away five months after being diagnosed, indicating that the presence of VEGF might suggest a more serious outcome for dogs with this type of cancer.
People also search for: dog mast cell tumor prognosis · VEGF in dog cancer · mast cell tumor treatment options
Abstract
UNLABELLED: The biologic behavior of mastocytomas is highly variable; some tumors have a benign behavior, whereas others exhibit aggressive growth and metastasis. Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis and a potential autocrine growth factor for neoplastic cells in various malignancies. MATERIAL AND METHOD: In the present study, we have investigated expression of VEGF in cutaneous tumor from a dog and combined immunohistochemical expression of VEGF with mast cell tryptase, CD117 and vimentin. RESULTS: Tumor cells were positive for VEGF, and inflammatory cells were negative. VEGF expression was found in tumor cells as a heterogeneous positive reaction, with cytoplasmic pattern and moderate to strong in intensity. Arrangement of tumor cells was in clusters, in deepest part, close to the proliferation front. The dog died 5 month from the diagnosis, and our observation suggest that VEGF secretion by tumor cells correlates with unfavorable prognosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20509299/