Peer-reviewed veterinary case report
Veterinary Regenerative Medicine for Musculoskeletal Disorders: Can Mesenchymal Stem/Stromal Cells and Their Secretome Be the New Frontier?
- Journal:
- Cells
- Year:
- 2020
- Authors:
- Mocchi, Michela et al.
- Affiliation:
- Department of Drug Sciences · Italy
Plain-English summary
Regenerative medicine is a field that focuses on repairing damaged cells and tissues, and in veterinary medicine, it often involves using special cells called mesenchymal stromal cells (MSCs). These cells can help heal injuries in dogs and horses, particularly those related to their muscles and joints. This review looks at what we currently know about using MSCs in treating these conditions and discusses the potential for using tiny particles called extracellular vesicles (EVs) as an alternative to MSCs. The goal is to develop these EVs into a product that can be safely used in clinical trials. Overall, the research suggests that MSCs and their secretions could be promising options for treating musculoskeletal issues in pets.
Abstract
Regenerative medicine aims to restore the normal function of diseased or damaged cells, tissues, and organs using a set of different approaches, including cell-based therapies. In the veterinary field, regenerative medicine is strongly related to the use of mesenchymal stromal cells (MSCs), which belong to the body repair system and are defined as multipotent progenitor cells, able to self-replicate and to differentiate into different cell types. This review aims to take stock of what is known about the MSCs and their use in the veterinary medicine focusing on clinical reports on dogs and horses in musculoskeletal diseases, a research field extensively reported in the literature data. Finally, a perspective regarding the use of the secretome and/or extracellular vesicles (EVs) in the veterinary field to replace parental MSCs is provided. The pharmaceuticalization of EVs is wished due to the realization of a Good Manufacturing Practice (GMP product suitable for clinical trials.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32545382/