Peer-reviewed veterinary case report
Dog developed nerve damage after vincristine chemo for cancer
By Hamilton, T A et al.·Published in Journal of the American Veterinary Medical Association·1991·Department of Veterinary Clinical Sciences College of Veterinary Medicine·View original on PubMed →
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Original publication title: Vincristine-induced peripheral neuropathy in a dog.
- Species:
- dog
Plain-English summary
A 12-year-old spayed Golden Retriever developed weakness and nerve issues after receiving 16 weekly chemotherapy injections of vincristine for a skin cancer called mycosis fungoides. Tests showed that the dog had nerve damage, which was confirmed by a biopsy of the affected nerve. After stopping the vincristine treatment, the dog's condition began to improve, and signs of nerve damage decreased over the following 2.5 months.
People also search for: dog weakness after chemotherapy · Golden Retriever nerve problems · vincristine side effects in dogs
Abstract
A 12-year-old spayed Golden Retriever with mycosis fungoides was treated by use of a chemotherapy protocol that included vincristine. After 16 weekly vincristine injections, the dog began to have signs of peripheral neuropathy. Results of electromyographic examination were consistent with muscle denervation, and motor nerve conduction velocity was depressed. Histologic examination of a common peroneal nerve biopsy specimen revealed severe nerve fiber degeneration. Clinical response and pathologic evidence of improvement were observed after the drug had been discontinued for 2.5 months.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/1850399/